Metformin therapy for diabetes in Prader-Willi syndrome
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چکیده
منابع مشابه
Metformin therapy for diabetes mellitus in Prader-Willi syndrome
Prader-Willi syndrome (PWS) is a rare neurogenetic disorder, which occurs in l per 15,000 live-born children. First described in 1956 by doctors Prader, Labhart and Willi, it is the commonest cause of syndromic obesity in childhood. Diabetes mellitus (DM) is a rare complication of children with PWS. A literature search revealed that most PWS children with DM have required insulin as their treat...
متن کاملPrader-Willi Syndrome
Prader-Willi syndrome is a neurogenetic disorder characterized by hypotonia and feeding difficulties in infancy, followed by hyperphagia, hypogonadism, mental retardation, and short stature. It was the first recognized microdeletion syndrome identified with high-resolution chromosome analysis, the first recognized human genomic imprinting disorder, and the first recognized disorder resulting fr...
متن کاملPrader-Willi syndrome.
Prader-Willi syndrome is a multi system disorder characterized by neonatal hypotonia, later obesity, hyperphagia and mental retardation. It occurs sporadically, either as a result of microdeletion of chromosome 15p (70%) or as a result of maternal disomy of chromosome 15 (30%). The major problems encountered by parents are those of hyperphagia, food-seeking and obesity, and conduct disorder, pa...
متن کاملPrader-willi Syndrome
Prader–Willi syndrome (PWS) is a genetic disorder due to loss of function of specific genes on chromosome 15. It occurs in males and females, no matter what race. As an infant, PWS shows itself in weak muscle tone (hypotonia, Pic. 1), feeding difficulties, poor growth, and delayed development. In the beginning during childhood, characterizes itself by having the kids develop an insatiable appet...
متن کاملCharacterization of Diabetes Mellitus in Japanese Prader-Willi Syndrome
Prader-Willi syndrome (PWS) is frequently associated with marked obesity and diabetes mellitus (DM). Although the overall frequency of DM in PWS ranges from 7-20%, there is only limited data available on Japanese patients. This study evaluated five factors associated with DM in PWS: 1) frequency, 2) age of onset, 3) risk factors, 4) long-term complications and 5) treatment. Sixty-five patients,...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1998
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107689809101116